Publications on Thermodynamics of Biological Systems


1.            U. Lucia, L. Bergandi, G. Grisolia, D. Fino, K. Mareschi, E Marini, A. G. S. Banche Niclot, E. Tirtei, S. D. Asaftei, F. Fagioli, A. Ponzetto & F. Silvagno. The exposure to extremely low frequency electromagnetic-fields inhibits the growth and potentiates the sensitivity to chemotherapy of bidimensional and tridimensional human osteosarcoma models. Biomedicine & Pharmacotherapy  177, 117162 (2024). doi: 10.1016/j.biopha.2024.117162

2.            U. Lucia, D. Fino, T. S. Deisboeck  & G. Grisolia. A Thermodynamic Perspective of Cancer Cells’ Volume/Area Expansion Ratio. Membranes 13, 895 (2023). DOI: 10.3390/membranes13120895

3.            U. Lucia & G. Grisolia. From Ion Fluxes in Living Cells to Metabolic Power Considerations. Mathematics 11, 2645 (2023). doi: 10.3390/math11122645

4.            U. Lucia, T.S. Deisboeck, A. Ponzetto & G. Grisolia. A Thermodynamic Approach to the Metaboloepigenetics of Cancer. International Journal of Molecular Sciences 24, 3337 (2023). doi: 10.3390/ijms24043337

5.            L. Bergandi, U. Lucia, G. Grisolia, I. C. Salaroglio, I. Gesmundo, R. Granata, R. Borchiellini, A. Ponzetto & F. Silvagno. Thermomagnetic Resonance Effect of the Extremely Low Frequency Electromagnetic Field on Three-Dimensional Cancer Models. International Journal of Molecular Sciences 23, 7955 (2022). DOI: 10.3390/ijms23147955

6.            G. Grisolia & U. Lucia. Why does thermomagnetic resonance affect cancer growth? A non‑equilibrium thermophysical approach. Journal of Thermal Analysis and Calorimetry 147, 5525–5531 (2022). DOI: 10.1007/s10973-022-11294-8

7.            G. Grisolia & U. Lucia. Thermo-fluid dynamic resonance in cancer cells. Journal of Physics: Conference Series 2177, 012040 (2022). DOI: 10.1088/1742-6596/2177/1/012040

8.            U. Lucia & G. Grisolia. Thermal resonance in living cells to control their heat exchange: Possible applications in cancer treatment. International Communications in Heat and Mass Transfer 131, 105842 (2022). DOI: 10.1016/j.icheatmasstransfer.2021.105842

9.            U. Lucia, G. Grisolia & T.S. Deisboek. Thermodynamics and SARS-CoV-2: neurological effects in post-Covid 19 syndrome. Atti dell’Accademia Peloritana dei Pericolanti 99, A3 (2021). DOI: 10.1478/AAPP.992A3

10.         G. Grisolia, M. Astori, A. Ponzetto, A. Vercesi & U. Lucia. Thermal Physics and Glaucoma II: Preliminary Evidences for a Thermophysical Design of a Possible Visible-Light-Photons Therapy. Applied Sciences  11, 6301 (2021). DOI: 10.3390/app11146301

11.         L. Bergandi, F. Silvagno, G. Grisolia, A. Ponzetto, E. Rapetti, M. Astori, A. Vercesi & U. Lucia. The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection. Applied Sciences 11, 5872 (2021). DOI: 10.3390/app11135872

12.         J. Teneggi, X. Chen, A. Balu, C. Barrett, G. Grisolia, U. Lucia, & R. Dzakpasu. Entropy estimation within in vitro neural-astrocyte networks as a measure of development instability. Physical Review E 103, 042412 (2021). DOI: 10.1103/PhysRevE.103.042412

13.         U. Lucia & G. Grisolia. Biofuels from Micro-Organisms: Thermodynamic Considerations on the Role of Electrochemical Potential on Micro-Organisms Growth. Applied Sciences 11, 2591 (2021). DOI: 10.3390/app11062591

14.         U. Lucia, G. Grisolia & T.S. Deisboek. A non-equilibrium thermodynamic approach to symmetry breaking in cancer. Atti dell’Accademia Peloritana dei Pericolanti 99, A1 (2021). DOI: 10.1478/AAPP.991A1

15.         U. Lucia, G. Grisolia & T.S. Deisboek. Seebeck-like effect in SARS-CoV-2 Bio-Thermodynamics. Atti dell’Accademia Peloritana dei Pericolanti 98, A6 (2020). DOI: 10.1478/AAPP.982A6

16.         G. Kaniadakis, M.M. Baldi, T.S. Deisboeck, G. Grisolia, D.T. Hristopolus, A.M. Scarfone, A. Sparavigna, T. Wada & U. Lucia. The k-statistic approach to epidemiology. Scientific Reports 10, 19949 (2020). DOI: 10.1038/s41598-020-76673-3

17.         U. Lucia, G. Grisolia & T.S. Deisboek. Alzheimer's Disease: A Thermodynamic Perspective. Applied Sciences 10, 7562 (2020). DOI: 10.3390/app10217562

18.         U. Lucia & G. Grisolia. Seebeck-Peltier Transition Approach to Oncogenesis. Applied Sciences 10, 7166 (2020). DOI: 10.3390/app10207166

19.         U. Lucia & G. Grisolia. Thermal Physics and Glaucoma: from Thermodynamic to Biophysical Considerations to Designing Future Therapies. Applied Sciences 10, 7071 (2020). DOI: 10.3390/app10207071

20.         U. Lucia & G. Grisolia. Non-Equilibrium Thermodynamic Approach to Ca2+-Fluxes in Cancer. Applied Sciences 10, 6737 (2020). DOI: 10.3390/app10196737

21.         U. Lucia & G. Grisolia.  How Life Works – A Continuous Seebeck-Peltier Transition in Cell Membrane? Entropy 22, 960 (2020). DOI: 10.3390/e22090960

22.         U. Lucia & G. Grisolia.  Thermal resonance and cell behaviour. Entropy 22, 774-785 (2020). DOI: 10.3390/e22070774

23.         U. Lucia, G. Grisolia, A. Ponzetto, L. Bergandi & F. Silvagno. Thermomagnetic resonance affects cancer growth and motility. Royal Society Open Science 7, 200299 (2020). DOI: 10.3390/e22070774

24.         U. Lucia, T.S. Deisboeck & G. Grisolia. Entropy-Based Pandemic Forecasting. Frontiers in Physics 8, 274 (2020). DOI: 10.3389/fphy.2020.00274

25.         U. Lucia & G. Grisolia. Resonance in thermal fluxes through cancer membrane. Atti dell'Accademia Peloritana dei Pericolanti  98, SC1-SC6 (2020). DOI: 10.1478/AAPP.981SC1

26.         U. Lucia, G. Grisolia, S. Francia & M. Astori.  Theoretical biophysical approach to cross-linking effects on eyes pressure. Physica A534, 122163 (2019). DOI: 10.1016/j.physa.2019.122163

27.         L. Bergandi, U. Lucia, G. Grisolia, R. Granata, I. Gesmundo, A. Ponzetto, E. Paolucci, R. Borchiellini, E. Ghigo & F. Silvagno. The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift. BBA - Molecular Cell Research 1866, 1389–1397 (2019). DOI: 10.1016/j.bbamcr.2019.05.006

28.         U. Lucia & G. Grisolia. Constructal Law and Ion Transfer in Normal and Cancer Cells. Proceedings of the Romanian Academy A Special Issue, 213-218 (2018).

29.         A. Ponzetto, J. Holton & U. Lucia. Cancer Risk in Patients With Cystic Fibrosis. Gastroenterology 154, 2282-2283 (2018). DOI: 10.1053/j.gastro.2018.02.040

30.         U. Lucia & T.S. Deisboeck. The importance of ion fluxes for cancer proliferation and metastasis: A thermodynamic analysis. Journal of Theoretical Biology 445, 1-8 (2018). DOI: 10.1016/j.jtbi.2018.02.019

31.         U. Lucia, G. Grisolia, A. Ponzetto & T.S. Deisboeck. Thermodynamic considerations on the role of heat and mass transfer in biochemical causes of carcinogenesis. Physica A490, 1164-1170 (2018). DOI: 10.1016/j.physa.2017.08.075

32.         U. Lucia, G. Grisolia & M.R. Astori. Constructal law analysis of Cl- transport in eyes aqueous humor. Scientific Reports 7, 6856 (2017). DOI: 10.1038/s41598-017-07357-8

33.         U. Lucia, G. Grisolia, A. Ponzetto & F. Silvagno. An engineering thermodynamic approach to select the electromagnetic wave effective on cell growth. Journal of Theoretical Biology 429, 181-189 (2017). DOI: 10.1016/j.jtbi.2017.06.029

34.         U. Lucia & G. Grisolia.  Second law efficiency for living cells. Frontiers of Bioscience 9, 270-275 (2017). DOI: 10.2741/s487

35.         U. Lucia & A. Ponzetto.  Some thermodynamic considerations on low frequency electromagnetic waves effects on cancer invasion and metastasis. Physica A467, 289-295 (2017). DOI: 10.1016/j.physa.2016.10.043

36.         U. Lucia, G. Grisolia, D. Dolcino, M. Astori, E. Massa & A. Ponzetto.  Constructal approach to bio-engineering: the ocular anterior chamber temperature. Scientific Reports 6, 31099 (2016). DOI: 10.1038/srep3109

37.         U. Lucia.  Electromagnetic waves and living cells: A kinetic thermodynamic approach. Physica A461, 577-585 (2016). DOI: 10.1016/j.physa.2016.06.079

38.         U. Lucia, A. Ponzetto & T.S. Deisboeck.  Constructal approach to cell membranes transport: Amending the ‘Norton-Simon' hypothesis for cancer treatment. Scientific Reports 6, 19451 (2016). DOI: 10.1038/srep19451

39.         U. Lucia & A. Ponzetto.  Thermodynamic considerations on Ca2+-induced biochemical reactions in living cells. Chemical Physics Letters 645, 84-87 (2016). DOI: 10.1016/j.cplett.2015.12.034

40.         U. Lucia, A. Ponzetto & T.S. Deisboeck.  Investigating the impact of electromagnetic fields on human cells: A thermodynamic perspective. Physica A443, 42-48 (2016). DOI: 10.1016/j.physa.2015.09.074

41.         U. Lucia.  Bioengineering thermodynamics: an engineering science for thermodynamics of biosystems. International Journal of Thermodynamics 18, 254-265 (2015). DOI: 10.5541/ijot.5000131605

42.         U. Lucia.  Bioengineering thermodynamics of biological cells. Theoretical Biology and Medical Modelling 12, 29 (2015). DOI: 10.1186/s12976-015-0024-z

43.         U. Lucia, G. Grazzini, B. Montrucchio, G. Grisolia, R. Borchiellini, G. Gervino, C. Castagnoli, A. Ponzetto & F. Silvagno.  Constructal thermodynamics combined with infrared experiments to evaluate temperature differences in cells. Scientific Reports 5, 11587 (2015). DOI: 10.1038/srep11587

44.         U. Lucia, A. Ponzetto T.S. Deisboeck. A thermodynamic approach to the ‘mitosis/apoptosis' ratio in cancer. Physica A 436, 246-255 (2015). DOI: 10.1016/j.physa.2015.05.046

45.         U. Lucia. A Link between Nano- and Classical Thermodynamics: Dissipation Analysis (The Entropy Generation Approach in Nano-Thermodynamics). Entropy 17, 1309-1328 (2015). DOI: 10.3390/e17031309

46.         U. Lucia, A. Ponzetto & T.S. Deisboeck. A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach. Scientific Reports  4, 6763 (2014). DOI: 10.1038/srep06763

47.         U. Lucia. The Gouy-Stodola Theorem in Bioenergetic Analysis of Living Systems (Irreversibility in Bioenergetics of Living Systems). Energies  7, 5717-5739 (2014). DOI: 10.3390/en7095717

48.         U. Lucia. Transport processes and irreversible thermodynamics analysis in tumoral systems. Physica A  410, 380-390 (2014). DOI: 10.1016/j.physa.2014.05.042

49.         U. Lucia. Thermodynamic approach to nano-properties of cell membrane. Physica A  407, 185-191 (2014). DOI: 10.1016/j.physa.2014.03.075

50.         U. Lucia. Entropy generation and cell growth with comments for a thermodynamic anticancer approach. Physica A  406, 107-118 (2014). DOI: 10.1016/j.physa.2014.03.053

51.         U. Lucia. Entropy generation approach to cell systems. Physica A 406, 1-11 (2014). DOI: 10.1016/j.physa.2014.03.050

52.         U. Lucia. Transport processes in biological systems: tumoral cells and human brain. Physica A  393, 327-336 (2014). DOI: 10.1016/j.physa.2013.08.066

53.         U. Lucia (Invited speaker) & B. Montrucchio.  Thermodynamic approach to the analysis of cancer: temperature and external fields. International Conference XXIX ESHO (European Society for Hyperthermic Oncology). Torino - National Car Museum, 13th June 2014. Panminerva Medica 56 (2 - Supplemento), 51-52 (2014).

54.         U. Lucia. Thermodynamic paths and stochastic order in open systems. Physica A  392, 3912-3919 (2013). DOI: 10.1016/j.physa.2013.04.053

55.         U. Lucia. Thermodynamics and cancer stationary states. Physica A  392, 3648-3653 (2013). DOI: 10.1016/j.physa.2013.04.033

56.         U. Lucia. Entropy generation, Brain Dynamics, and Thomas Aquinas. Journal of Human Thermodynamics  9, 55-64 (2013).

57.         U. Lucia.  Molecular refrigerators: a new approach in anti-cancer therapy. OA Medical Hypothesis  1, 9-12 (2013). DOI: 10.13172/2053-0781-1-1-925

58.         U. Lucia. Different chemical reaction times between normal and solid cancer cells. Medical Hypotheses  81, 58-61 (2013). DOI: 10.1016/j.mehy.2013.04.007

59.         U. Lucia & G. Maino. Entropy generation in biophysical systems. EPL (Europhysics Letter) A Letters Journal Exploring the Frontiers of Physics  101, 56002 (2013). DOI: 10.1209/0295-5075/101/56002

60.         U. Lucia. Irreversible human brain. Medical Hypothesis  80, 114-116 (2013). DOI: 10.1016/j.mehy.2012.11.001

61.         U. Lucia. Irreversibility in biophysical and biochemical engineering. Physica A  391, 5997–6007 (2012). DOI: 10.1016/j.physa.2012.07.018

62.         U. Lucia & G. Maino.  Thermodynamical analysis of the dynamics of tumour interaction with the host immune system. Physica A  313, 569-577 (2002). DOI: 10.1016/S0378-4371(02)00980-9